IOV 2015

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This is a recent animation on Meningitis that we created with a very quick turn around. The content and script were relatively simple and straight forward so we focused on the pacing and camera moves. Thanks for watching. 

Pulse Biosciences

IOV is proud to be working with Pulse Biosciences, creating a series of animations depicting their new electro-pulse technology.

“The Nano-Pulse Electro-Signaling (NPES) pulses are applied directly to tissue, creating a transient opening of small pores in cell and organelle membranes. We have found that by controlling this disruption of the cellular organelles, we can direct the cellular response quite specifically[1], [2], [3], [4], [5], [6]. For the treatment of cancer we believe that we can trigger a signaling cascade within the tumor cells that ends in immunogenic apoptosis. Immunogenic apoptosis is a process in which cells are induced to die in a natural way, initiating their own programmed cell death, engaging the immune system to clear damaged, diseased, or aged cells and enrolling cytotoxic T cells to recognize and eliminate cells of the same tumor type.”

More information on Pulse Biosciences can be found on their website.

Undisclosed Agency

Multiple 3d illustrations were ordered to be utilized in a convention poster and brochure pamphlet. Among the elements created by us were cell evolution-differentiation, chromosome and DNA strands with histones, and Mitochondria.

Malignant Growth Simulation

A recent series of animations,  has called for quick solutions. This has challenged us to create scenes that convey complicated topics with less complicated setups. In this scene about Neoplasia we have shown an exaggerated proliferation of malignant cells among a bed of healthy cells. The growth of the cells veers a bit from realism, with the effect of proliferation similar to “popcorn” This visual narrative synced with the the voice-over which reads:

“Unlike normal cells, malignant neoplasms grow at an accelerated rate without growth factor.  They are not inhibited by density dependencies and will invade adjacent tissue.
The unchecked growth of cells and their disregard for neighboring tissue seems to indicate poor cell-to-cell communication within the malignant neoplasia.”

Some projects require creative problem solving to get the story told. This relatively straight-forward simulation was re purposed with varying setups and cameras for multiple scenes. We will be posting some more examples from this series as they are completed.

Sourcebook Image 2015

It is that time a year again when we hustle to put together a new image and layout for the Medical Illustration Sourcebook. This year we used an existing scene from an educational animation on Crohn’s Disease & Colitis for healthcare professionals . The original scene depicted white blood cells attacking bacteria in the intestine (as can be seen on our home page). We added detail to the wall lining and increased the realism of the bacteria and WBC. An intensified cinematic look was achieved through extra lighting and effects. The idea was to achieve a more “National Geographic” look and feel. The 2015 addition of the Medical Illustration Sourcebook will be released in September of this year!

Lipid Simulations

IOV is developing an MOA (client undisclosed),  that involves cell function and lipid layers. Here we are showing some R&D involving lipid interacting and cell components. We will be increasing the level of detail in both the elements and the motion. Another exciting project underway, involving science and simulations!

Nortis BIO

We are honored to be creating product renders for Nortis Bio’s bio chip and supporting elements:

“About the size of a credit card, Nortis’ unique microfluidic chips can be used to grow tissue microenvironments by seeding cells into tubular voids within extracellular matrix gels. The chip design offers the flexibility to generate a variety of tissue architectures based on cell types and matrix materials selected.

Small, portable perfusion platforms house the disposable chips and supporting media and collection reservoirs. Three-shelved docking stations that reside in a standard tissue culture incubator increase experimental throughput and flexibility by enabling up to twelve independent experiments to be run at a time. Perfusion through both the tissue lumen and surrounding extralumenal space allow physico-chemical gradients to be created and perfusion fluids and cells to be collected for downstream analysis. Each docking station shelf can easily be removed and the small perfusion platform/chip assemblies accommodate easy transport between the cell culture incubator, laminar flow hood, and microscope stage.”

More can be read about this biotechnology at